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. 2021 Dec 8;11:23587. doi: 10.1038/s41598-021-02864-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of etanercept on body weight, tissue weight, systolic blood pressure and heart rate. (a) Experimental protocol. Control group received DMSO i.p. injection twice per week for 4 weeks and normal saline s.c. injection twice per week for 8 weeks. AA group received AA (3 mg/kg) i.p. injection twice per week for 4 weeks and normal saline s.c. injection twice per week for 8 weeks. AA + ETN group received AA (3 mg/kg) i.p. injection twice per week for 4 weeks and ETN (5 mg/kg) s.c. injection twice per week for 8 weeks. Body weight was measured twice per week for 8 weeks. Blood pressure and heart rate were measured at 0, 4, and 8 weeks after the start of the experiment. (b) Changes in body weight. (c) Heart and kidney weight to body weight ratio. (d) Changes in systolic blood pressure. (e) Changes in heart rate. Values are means ± SEM, n = 8. *** P < 0.001. AA, aristolochic acid; DMSO, dimethyl sulfoxide; ETN, etanercept; BP, blood pressure; HR, heart rate; Ctrl, control.