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. 2021 Dec 8;11:23582. doi: 10.1038/s41598-021-02900-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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BW dosage and pharmacokinetic profile. (A) Kinetic concentration of BW in plasma and brain after a single IP injection of BW at 10 mg/kg. (B) Brain to plasma ratio of data presented on graph (A) (C) PK profile of BW after administration per os (PO), intravenous (IV) or subcutaneous (SC) in CD-1 mice. (D) Plasma and brain concentration of BW from our study animals treated with either 1 or 3 mg/kg/d.