Table 2.
Pharmacokinetic properties of BW following different route of administration: per os (PO), intravenous (IV) or subcutaneous (SC).
| IV 2 mg/kg | PO 10 mg/kg | SC 10 mg/kg | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n1 | n2 | n3 | mean | n1 | n2 | n3 | mean | n1 | n2 | n3 | mean | |
| C0/Cmax (ng/mL) | 406 | 290 | 366 | 354 | 36.5 | 61.5 | 132 | 77 | 935 | 1100 | 1010 | 1015 |
| Tmax (h) | – | – | – | – | 0.25 | 0.50 | 1.00 | 0.58 | 0.08 | 0.25 | 0.25 | 0.19 |
| T1/2 (h) | 0.98 | 0.84 | 0.98 | 0.93 | 4.50 | 2.01 | 1.13 | 2.55 | 1.65 | 1.14 | 1.2 | 1.37 |
| AUC0-inf (ng.h/mL) | 289 | 221 | 199 | 236 | 239 | 294 | 302 | 278 | 1938 | 2031 | 2246 | 2072 |
| AUCExtra (%) | 4.8 | 3.5 | 4.5 | 4.3 | 29.9 | 7.2 | 1.0 | 12.7 | 3.3 | 0.7 | 1.4 | 1.8 |
| Bioavailability (%) | 100% | 4.7% | 35% | |||||||||