Table 2.
Univariate and multivariate analyses of the association between various clinical characteristics and OS.
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HRadj (95% CI) | P value | |
| Age, < 75 years | 0.73 (0.56–0.96) | 0.021 | 0.89 (0.64–1.24) | 0.48 |
| Sex, male | 1.76 (1.36–2.30) | < 0.001 | 1.36 (0.89–2.06) | 0.15 |
| Smoking status, ≥ 10 pack-years | 1.97 (1.52–2.58) | < 0.001 | 1.17 (0.74–1.86) | 0.51 |
| Histology, squamous | 1.88 (1.39–2.56) | < 0.001 | 1.19 (0.84–1.68) | 0.32 |
| Chemotherapy | ||||
| Platinum doublet | 0.79 (0.62–1.01) | 0.060 | 0.83 (0.61–1.14) | 0.26 |
| TKI | 0.52 (0.41–0.67) | < 0.001 | 0.66 (0.49–0.88) | 0.0047 |
| Recurrence | 0.62 (0.47–0.80) | 0.0004 | 0.62 (0.47–0.83) | 0.0011 |
| Performance status, ≥ 2 | 3.92 (2.53–5.84) | < 0.001 | 3.36 (2.13–5.31) | < 0.001 |
| COPD | 1.62 (1.25–2.09) | 0.0002 | 1.06 (0.78–1.43) | 0.72 |
Comparisons were made by means of chi-squared tests unless otherwise indicated.
Significant values are in [italics].
TKI Tyrosine kinase inhibitors.