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. 2021 Dec 8;12:7147. doi: 10.1038/s41467-021-27414-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Molecular surface representation of SLC7A11 showing the bound L-Glu ligand. b Zoomed in view of the ligand binding site with differences between TM8 in the apo (coloured) and bound (grey) states. The EM density for the ligand is shown, threshold 8 sigma. c Cryo-EM density for TM8 for the apo (yellow) and l-Glu bound (grey) structures. d Structural differences on TM8 between bound and unbound forms in relation to the re-positioning of Arg135 on TM3 and subsequent repositioning of Phe336. e Transport assays of cystine uptake for cells transfected with a plasmid containing wild type or variant forms of SLC7A11 or the empty plasmid as a negative control. n = 12 independent experiments, data are presented as mean values and error bars s.d.