Table 3.
Outcome measures
| OUTCOME MEASURES | |||||||
|---|---|---|---|---|---|---|---|
| Measure | Baseline a | Post-Intervention |
Adjusted effect size & (95% CI): Baseline vs Post-intervention | ||||
| All b | No Pathway c | With pathway d | Adjusted effect size # (95% CI): No pathway vs with pathway | ||||
| In-hospital mortality^ | All | 81 | 125 | 61 | 64 | 0.6 | 1.1 |
| Sepsis | (11.1) | (11.7) | (14.9) | (9.7) | (0.4, 0.9) ** | (0.8, 1.5) | |
| Septic Shock | 29 | 50 | 26 | 24 | 0.3 | 1.3 | |
| (25.4) | (29.8) | (44.1) | (22.0) | (0.2, 0.7) ** | (0.7, 2.2) | ||
| Sepsis Alone | 52 | 75 | 35 | 40 | 0.6 | 1.0 | |
| (8.4) | (8.3) | (10.0) | (7.3) | (0.4, 1.1) | (0.7, 1.5) | ||
| Suspected Sepsis | - | 61 | 30 | 31 | 0.5 | - | |
| (10.2) | (12.7) | (8.5) | (0.3, 1.0) | ||||
| 30-day post discharge mortality^ | All Sepsis | 124 (16.9) | 184 (17.2) | 79 (19.3) | 105 (15.9) | 0.8 (0.5, 1.1) | 1.0 (0.8, 1.4) |
| Septic Shock | 35 | 63 | 29 | 34 | 0.4 | 1.4 | |
| (30.7) | (37.5) | (49.2) | (31.2) | (0.2, 0.9) ** | (0.8, 2.5) | ||
| Sepsis Alone | 89 | 121 | 50 | 71 | 0.8 | 0.9 | |
| (14.4) | (13.4) | (14.2) | (12.9) | (0.6, 1.3) | (0.7, 1.3) | ||
| Suspected Sepsis | - | 92 | 40 | 52 | 0.7 | - | |
| (15.3) | (16.9) | (14.3) | (0.4, 1.1) | ||||
| ICU admission^ | All | 194 (26.5) | 187 | 68 | 119 | 1.1 | 0.5 |
| Sepsis | (17.5) | (16.6) | (18.0) | (0.8, 1.6) | (0.4, 0.7) ** | ||
| Septic Shock | 50 | 67 | 19 | 48 | 1.7 | 0.8 | |
| (43.9) | (39.9) | (32.2) | (44.0) | (0.9, 3.5) | (0.5, 1.4) | ||
| Sepsis Alone | 144 | 120 | 49 | 71 | 0.9 | 0.5 | |
| (23.3) | (13.3) | (14.0) | (12.9) | (0.6, 1.4) | (0.3, 0.6) ** | ||
| Suspected Sepsis | - | 113 | 57 | 56 | 0.7 | - | |
| (18.8) | (24.2) | (15.4) | (0.4, 1.0) | ||||
| Length of ICU stay (days)* | All Sepsis | 2.3 (0.9, 4.2) | 2.3 (1.1, 4.9) | 2.5 (0.9, 5.4) | 2.3 (1.2, 4.5) | 1.1 (0.8, 1.5) | 0.9 (0.7, 1.0) |
| Septic Shock | 2.6 (1.1, 4.5) | 2.6 (1.5, 4.0) | 2.3 (1.6, 3.2) | 2.7 (1.5, 4.4) | 0.6 (0.3, 1.1) | 1.1 (0.8, 1.6) | |
| Sepsis Alone | 2.2 (0.8, 4.2) | 2.3 (1.0, 5.4) | 2.8 (0.8, 6.0) | 2.3 (1.1, 4.5) | 1.1 (0.8, 1.7) | 0.8 (0.6, 1.0) | |
| Suspected Sepsis | - | 2.9 (1.7, 5.1) | 3.3 (1.8, 5.1) | 2.8 (1.5, 5.0) | 1.1 (0.8, 1.7) | - | |
| Length of non-ICU hospital stay (days)* | All Sepsis | 5.4 (2.7, 10.3) | 5.2 (2.9, 9.8) | 5.8 (3.0, 10.4) | 4.9 (2.7, 9.3) | 1.1 (1.0, 1.2) | 1.0 (0.9, 1.1) |
| Septic Shock | 4.6 (1.7, 9.5) | 5.1 (1.8, 9.7) | 4.4 (1.9, 10.1) | 5.3 (1.5, 9.3) | 1.0 (0.8, 1.4) | 0.9 (0.7, 1.1) | |
| Sepsis Alone | 5.4 (2.8, 10.5) | 5.4 (3.0, 9.8) | 6.0 (3.2, 10.4) | 4.9 (2.8, 9.4) | 1.1 (1.0, 1.3) | 1.0 (0.9, 1.1) | |
| Suspected Sepsis | - | 4.1 (2.0, 7.8) | 5.0 (2.3, 9.8) | 3.7 (1.9, 6.7) | 1.3 (1.1, 1.5) ** | - | |
CI confidence interval; IV intravenous; ICU intensive care unit.
^ n (%), effect estimate = odds ratio; # post-intervention no pathway vs with pathway.
& baseline vs post-intervention; * median (IQR), effect estimate = hazard ratio.
a N (Baseline) All Sepsis = 732; Septic Shock = 114; Sepsis Alone = 618.
b N (Post-Intervention) All Sepsis = 1070; Septic Shock = 168; Sepsis Alone = 902.
c N (No Pathway) All Sepsis = 410; Septic Shock = 59; Sepsis Alone = 351.
d N (With Pathway) All Sepsis = 660; Septic Shock = 109; Sepsis Alone = 551.
** - 95% Confidence limits indicate a significant change.