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. 2021 Dec 8;4:1374. doi: 10.1038/s42003-021-02895-4

Fig. 3. HTT HEAT domains are conformationally flexible in the absence of HAP40.

Fig. 3

a Representative cryo-EM 2D class averages of HTT Q23. Scale bar (white) shown in the bottom middle panel is 90 Å. Blue arrowhead denotes the N-HEAT domain in which its central cavity (orange arrowhead) is more clearly defined. Purple arrowhead denotes the less well-defined C-HEAT domain, perhaps due to conformational flexibility relative to the N-HEAT. b Cryo-EM volume of HTT resolved to ~12 Å shown with model of HTT-HAP40 (PDBID: 6X9O) fit to the map. Regions of map and model are displayed with N-HEAT in blue, bridge domain in green, C-HEAT in purple and HAP40 in yellow.