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. 2021 Dec 8;11:623. doi: 10.1038/s41398-021-01737-5

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The blue line shows the best fitting line and standard error between CUD gene expression (of KEGG Cocaine Addiction Pathway genes) and neuronal signatures of ibrutinib (collapsing across dose, time and cell line; r_dlPFC = −0.16, r_hippocampus = −0.25 and r_midbrain = −0.04). Genes were labeled if they were in the negative diagonal of the plot (green points). Differential expression of FOSB in the dlPFC was windsorized for visualization purposes.