Fig. 5. Ibrutinib influences cocaine-induced startle response, cocaine-induced seizures and cocaine consumption in Drosophila melanogaster.

Sample sizes were as follows: n = 61 (♂control), 140 (♂cocaine), 132 (♂cocaine + ibrutinib), 66 (♀control), 141 (♀cocaine), 142 (♀cocaine + ibrutinib). A Dotplot showing the cocaine startle response by condition. B Barplot showing the average seizure activity during the startle response across conditions with 95% confidence intervals. C Dotplot showing cocaine consumption across conditions. Colored dots represent individual flies and the black dot displays the average for each group and the standard error.ns p > 0.05. *p < 0.05. **p < 0.01. ***p < 0.001. ****p < 0.001.