Table 3.
Analysis of Vitamin D supplementation, compared with placebo, and change in total or allergen-specific IgE level between the exit and randomization visits.
|
Unadjusted
|
Adjusted
|
|||||
|---|---|---|---|---|---|---|
| Parameter | β | 95% CI | P | β | 95% CI | P |
| Treatment | ||||||
| Change in: | ||||||
| Log10 total IgE (IU/mL) | 0.011 | −0.056 – 0.077 | 0.75 | 0.007 | −0.061 – 0.074 | 0.85 |
| IgE to Der p (IU/ml) | 1.467 | −0.901 – 3.835 | 0.22 | 1.239 | −1.170 – 3.648 | 0.31 |
| IgE to Bla g (IU/ml) | 0.592 | –0.341 – 1.525 | 0.21 | 0.501 | −0.422 – 1.424 | 0.29 |
| Treatment (in atopic subjects only [n=138]) | ||||||
| Change in: | ||||||
| Log10 total IgE (IU/mL) | 0.015 | −0.051 – 0.081 | 0.65 | 0.012 | −0.055 – 0.080 | 0.72 |
| IgE to Der p (IU/ml) | 1.810 | −1.188 – 4.808 | 0.23 | 1.297 | −1.757 – 4.352 | 0.40 |
| IgE to Bla g (IU/ml) | 0.755 | −0.427 – 1.936 | 0.21 | 0.640 | −0.520 – 1.801 | 0.28 |
Models adjusted for sex, race, study site, and time in the study.
Der p= Dermatophagoides pteronyssinus, Bla g= Blattella germanica
Atopy was defined as a total IgE ≥100 IU/ml or an IgE to Der p ≥0.35 IU/ml or an IgE to Bla g ≥0.35 IU/ml