Table 2.
Non-inferiority of PEG-rhGH every other week (QOW) versus weekly PEG-rhGH (QW) and daily rhGH (QD).
| Group | HtSDSCA | Annualized HV | ||||
|---|---|---|---|---|---|---|
| Mean (SD) | 97.5%CI | Δ | Mean (SD) | 97.5%CI | Δ | |
| QW | 0.55 (0.32) | 0.49, 0.60 | 10.82 (2.67) | 10.35, 11.28 | ||
| QOW | 0.37 (0.24) | 0.33, 0.42 | 8.98 (2.10) | 8.62, 9.35 | ||
| DIFF(QW − QOW) | 0.17 (0.28) | −Infinite, 0.23 | 0.11 | 1.83 (2.40) | −Infinite, 2.35 | 2.16 |
| QD | 0.54 (0.29) | 0.49, 0.60 | 10.82 (2.83) | 10.32, 11.33 | ||
| QOW | 0.37 (0.24) | 0.33, 0.42 | 8.98 (2.10) | 8.62, 9.35 | ||
| DIFF(QD − QOW) | 0.17 (0.27) | −Infinite, 0.23 | 0.11 | 1.84 (2.48) | −Infinite, 2.38 | 2.16 |
| QW | 0.55 (0.32) | 0.50, 0.59 | 10.82 (2.67) | 10.41, 11.22 | ||
| QD | 0.54 (0.29) | 0.50, 0.59 | 10.82 (2.83) | 10.38, 11.27 | ||
| DIFF(QW − QD) | −0.01 (0.34) | −0.08, 0.06 | 0.00 | −0.01 (2.75) | −0.60, 0.59 | 0.00 |
DIFF, difference; Δ, non-inferiority threshold; PEG-rhGH, PEGylated recombinant human growth hormone; HtSDSCA, height SD scores for chronological age; HV, height velocity.