Table 3.

Non-inferiority of PEG-rhGH every other week (QOW) versus weekly PEG-rhGH (QW) and daily rhGH (QD) stratified by GH peak (<7 or ≥7 μg/L).

	HtSDSCA
Group	Mean (SD)	97.5%CI	Δ
GH peak <7 μg/L
QW	0.54 (0.35)	0.46, 0.62
QOW	0.39 (0.25)	0.33, 0.45
DIFF(QW − QOW)	0.15 (0.31)	−Infinite, 0.24	0.11
QD	0.55 (0.32)	0.48, 0.63
QOW	0.39 (0.25)	0.33, 0.45
DIFF(QD − QOW)	0.17 (0.29)	−Infinite, 0.26	0.11
QW	0.54 (0.35)	0.47, 0.61
QD	0.55 (0.32)	0.49, 0.62
DIFF(QW − QD)	−0.01 (0.34)	−0.11, 0.09	0.00
GH peak ≥7 μg/L
QW	0.55 (0.28)	0.48, 0.62
QOW	0.36 (0.23)	0.29, 0.42
DIFF(QW − QOW)	0.20 (0.26)	−Infinite, 0.28	0.11
QD	0.53 (0.26)	0.46, 0.60
QOW	0.36 (0.23)	0.29, 0.42
DIFF(QD − QOW)	0.18 (0.24)	−Infinite, 0.26	0.956
QW	0.55 (0.28)	0.49, 0.61
QD	0.53 (0.26)	0.47, 0.59
DIFF(QW − QD)	0.02 (0.27)	−0.07, 0.11	0.00

DIFF, difference; Δ, non-inferiority threshold; PEG-rhGH, PEGylated recombinant human growth hormone; HtSDS_CA, height SD scores for chronological age.