Table 1.
Laminin-332 pemphigoid patients with IgG reactivity against a single subunit of laminin-332.
| ID | Age | Sex | IIF Dermal | Laminin Domain reactivity | Other autoantibodies |
|---|---|---|---|---|---|
| LAMA3-IgG1 | 85 | M | +40 | α3 | – |
| LAMA3-IgG2 | 61 | M | +10 | α3 | – |
| LAMA3-IgG3 | 63 | M | +10 | α3 | BP180/BP230 |
| LAMA3-IgG4 | 50 | F | +10 | α3 | – |
| LAMB3-IgG1 | NR | NR | +10 | β3 | BP180 |
| LAMB3-IgG2 | NR | NR | +10 | β3 | – |
| LAMB3-IgG3 | 49 | F | +10 | β3 | – |
| LAMB3-IgG4 | 78 | M | +10 | β3 | – |
| LAMC2-IgG1 | 56 | F | – | γ2 | – |
| LAMC2-IgG2 | 74 | M | +10 | γ2 | – |
| LAMC2-IgG3 | 84 | M | +10 | γ2 | P200 |
| LAMC2-IgG4 | 69 | M | +10 | γ2 | – |
IIF, indirect immunofluorescence; NR, No record. IIF was performed on salt split human skin with serial dilution to 1:10 and 1:40. Laminin subunit reactivity was determined by immunoblotting. The presence of BP180, BP230, and collagen 7 antibodies was assessed by ELISA. Notably, neither patient with BP180 antibodies demonstrated epidermal staining. Immunoblotting was used to screen sera for reactivity against p200.