Table 1.
Antifungal activity of three hydroxyketones and FLC against Candida species.
| Strainsa | MICs (μg/mL) |
||||
|---|---|---|---|---|---|
| Hinokitiol | Tropolone | Maltol | FLC | ||
| C. albicans | SC5314 | 2 | 16 | >128 | 2 |
| ATCC10231 | 2 | 16 | >128 | 1 | |
| C. tropicalis | CT-LY1 | 2 | 32 | >128 | 1 |
| CT2 | 1 | 32 | >128 | 1 | |
| C. parapsilosis | CP-LY8 | 2 | 32 | >128 | 1 |
| CP001 | 1 | 8 | >128 | 0.5 | |
| C. glabrata | CG-LY12 | 0.5 | 8 | >128 | 1 |
| CG1 | 0.5 | 8 | >128 | 0.5 | |
| C. krusei | CK-LY16 | 1 | 16 | >128 | 2 |
| CK1 | 2 | 64 | >128 | 2 | |
a
ATCC10231 is a standard strain of C. albicans obtained from ATCC (American Type culture collection). SC5314 is a wild-type C. albicans strain. Other Candida strains were clinically derived.