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The schematic diagram of therapeutic mechanism of Nar against Hcy induced endothelial dysfunction. Obviously, Nar can elevate AMPKα/Sirt1 signaling pathway consequently rescue the Ca2+ disrupted mitochondrial function and reduce the ROS production. Furthermore, activated AMPKα/Sirt1 signaling pathway will upregulate the activity of downstream protein of eNOS subsequently increase the production of NO, ultimately ameliorate the ED.
