TABLE 1.
Quantitative alterations of some of the components of the HPA axis
| Componenta | Result forb:
|
Pc | n | |
|---|---|---|---|---|
| WT mice | YGR mice | |||
| CRH immunoreactivity in the ME | 10.7 ± 1.8 | 4.9 ± 0.8 | <0.001 | 5 |
| POMC mRNA in the AL | 34.5 ± 9.6 | 12.6 ± 3.3 | <0.01 | 5 |
| ACTH immunoreactivity in the AL | 24.0 ± 7.3 | 10.4 ± 3.7 | <0.01 | 7 |
| ACTH levels in the serum | 43 ± 33 | 110 ± 46 | <0.04 | 6 |
| CORT levels in the serum | 41 ± 18 | 9 ± 9 | <0.005 | 7 |
a
ME, median eminence; AL, anterior lobe of the pituitary; CORT, corticosterone.
b
Values are given in arbitrary units, except that ACTH levels are given in picograms per milliliter and CORT levels are given in nanograms per milliliter.
c
Determined by the Student t test.