Table 3.
Univariate analysis of factors associated with disease control
| Characteristic | HR | 95% CI | P value |
|---|---|---|---|
| Univariate analysis | |||
| Age* | 1.00 | 0.97-1.03 | .72 |
| Preoperative PSA* | 1.09 | 1.06-1.14 | < .01 |
| Gleason score at biopsy | |||
| 4-6 | - | - | - |
| 7 | 1.93 | 1.24-3.02 | < .01 |
| 8-10 | 5.00 | 2.53-9.88 | < .01 |
| Interval from biopsy to RP* | 1.00 | 1.00-1.00 | .79 |
| Prostate volume* | 1.00 | 0.98-1.01 | .60 |
| Gleason score at RP | |||
| 5-6 | - | - | - |
| 7 | 2.41 | 1.45-4.02 | < .01 |
| 8-9 | 9.37 | 4.77-18.39 | < .01 |
| Gleason grade | |||
| 1-2 | - | - | - |
| 3 | 1.91 | 1.08-3.38 | .03 |
| 4-5 | 5.95 | 3.35-10.57 | < .01 |
| Robot-assisted RP, no vs yes | 0.83 | 0.47-1.48 | .53 |
| Nerve-sparing RP, no vs yes | 1.18 | 0.74-1.89 | .48 |
| Extraprostatic extension, yes vs no | 1.82 | 1.08-3.38 | .03 |
| Pathologic tumor stage | |||
| 2 | - | - | - |
| 3 | 1.46 | 0.95-2.24 | .08 |
| Foci of margin involvement | |||
| 1 | - | - | - |
| 2 + | 1.50 | 0.97-2.31 | .07 |
| Maximal margin width* | 1.09 | 1.04-1.14 | < .01 |
| Cumulative margin width* | 1.07 | 1.04-1.10 | < .01 |
Abbreviations: CI = confidence interval; HR = hazard ratio; PSA = prostate specific antigen; RP = radical prostatectomy.
bolding indicates statistically significant values.
*Continuous variables are denoted with an asterisk where HR equals 1 unit of change. All other variables are categorical.