TABLE 1.
IC50 values of SU6656 and SU6657
| Kinase | IC50 (n)a
|
|
|---|---|---|
| SU6656 | SU6657 | |
| Src | 0.28 ± 0.03 (64) | 0.34 ± 0.09 (10) |
| Fyn | 0.17 ± 0.06 (14) | 0.42 ± 0.18 (15) |
| Yes | 0.02 ± 0.01 (9) | 0.03 ± 0.01 (9) |
| Lyn | 0.13 ± 0.04 (4) | NT |
| Lck | 6.88 ± 1.52 (5) | 16.23 ± 9.42 (4) |
| PDGFRβ | >10 (1) | 1.02 (1) |
| FGFR1 | 3.59 ± 0.88 (3) | 0.66 ± 0.21 (11) |
| IGF1R | >20 (2) | 32.01 ± 1.02 (2) |
| Met | 3.6 ± 0.16 (2) | 0.84 ± 0.15 (8) |
| Frk | 7.58 ± 1.66 (5) | 7.28 ± 3.27 (9) |
| Csk | 7.63 ± 0.17 (2) | NT |
| Abl | 1.74 ± 0.29 (3) | NT |
| Cdk2 | >10 (4) | 1.63 (1) |
a
Mean IC50 values (micromolar) ± standard error of the mean. NT, not tested.