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. 2021 Dec 7;28(1):e100458. doi: 10.1136/bmjhci-2021-100458

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Hospital and long-term outcomes by trajectories of acute kidney injury (AKI) in hospitalised adult patients stratified by ICU admission. (A) Trajectories of AKI in hospitalised adult patients who have been admitted to ICU during hospitalisation. 1-year follow-up outcome was reported among hospital survivors. (B) Adjusted Kaplan-Meier survival curves and number at risk by AKI trajectories injury in hospitalised adult patients who have been admitted to ICU during hospitalisation. Propensity score based inverse weighting was used to plot adjusted Kaplan-Meier curves where propensity of being in a trajectory group was calculated using multinomial logistic model that included patient demographics (age, gender, ethnicity) and Charlson Comorbidity Index score. (C) HRs for all-cause mortality by AKI trajectories in hospitalised adult patients who have been admitted to ICU during hospitalisation. (D) Trajectories of AKI in hospitalised adult patients who have not been admitted to ICU during hospitalisation. 1-year follow-up outcome was reported among hospital survivors. (E) Adjusted Kaplan-Meier survival curves and number at risk by AKI trajectories in hospitalised adult patients who have not been admitted to ICU at any time during hospitalisation. Propensity score based inverse weighting was used to plot adjusted Kaplan-Meier curves where propensity of being in a trajectory group was calculated using multinomial logistic model that included patient demographics (age, gender, ethnicity) and Charlson Comorbidity Index score. (F) Hazard ratios for all-cause mortality by AKI trajectories in hospitalised adult patients who have not been admitted to ICU at any time during hospitalisation. ^aSignificantly different from no AKI group (Bonferroni-adjusted p<0.05). ^bSignificantly different from rapidly reversed AKI group (Bonferroni-adjusted p<0.05). ^cSignificantly different from persistent AKI with renal recovery (Bonferroni-adjusted p<0.05). ^dAdjusted for age, gender, ethnicity, Charlson Comorbidity Index score, and need for mechanical ventilation for more than 2 days and need for ICU admission for more than 2 days. ^eAdjusted for age, gender, ethnicity, and Charlson Comorbidity Index score. ICU, intensive care unit; RRT, renal replacement therapy.