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. 2021 Dec 8;7(3):e002038. doi: 10.1136/rmdopen-2021-002038

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Visual representation of the mean annual radiographic progression by three different subgroups in the clinical trial (A) and real-life cohort (B). (A) Observed progression is the smallest in the absence of both clinical and biochemical inflammation (−0.43±0.54, n=9), higher when at least either clinical or biochemical inflammation is present (taSJC−/taCRP+ or taSJC+/taCRP−: 0.32±2.84, n=32) and highest when both clinical and biochemical inflammation are present (taSJC+/taCRP+: 1.47±3.35, n=33; p=0.05). (B) Observed progression is the smallest in the absence of both clinical and biochemical inflammation (0.54±5.90, n=41), higher when at least either clinical or biochemical inflammation is present (2.52±6.49, n=52) and highest when both clinical and biochemical inflammation are present (6.92±12.26, n=12; p=0.046). taCRP, time-averaged C reactive protein; taSJC, time-averaged swollen joint count.