Table 1.
Pooled results of FujiLAM in the diagnosis of adult patients with tuberculosis.
| Sensitivity | Specificity | Positive LR | Negative LR | Diagnostic OR | SROC | |
|---|---|---|---|---|---|---|
| MRS | ||||||
| Overall | 0.70 (0.63–0.78) | 0.93 (0.89–0.97) | / | / | / | / |
| HIV infected | 0.75 (0.72–0.79) | 0.90 (0.88–0.92) | 7.75 (6.29–9.55) | 0.22 (0.24–0.31) | 29.25 (21.36–40.04) | 0.88 |
| HIV uninfected | 0.58 (0.51–0.66) | 0.98 (0.97–0.99) | 31.07 (12.57–76.79) | 0.40 (0.29–0.55) | 92.51 (39.10–218.92) | 0.93 |
| CD4 cell > 200 | 0.46 (0.36–0.56) | 0.98 (0.96–0.99) | 21.7 (10.04–46.92) | 0.56 (0.46–0.67) | 38.73 (16.0–93.71) | / |
| CD4 cell ≤ 200 | 0.81 (0.77–0.84) | 0.84 (0.80–0.88) | 5.1 (3.41–7.63) | 0.22 (0.19–0.27) | 24.31 (15.89–37.17) | / |
| Frozen urine samples | 0.73 (0.68–0.78) | 0.92 (0.88–0.96) | / | / | / | / |
| Fresh urine samples | 0.64 (0.44–0.92) | 0.96 (0.89–1.00) | / | / | / | / |
| Cerebrospinal fluid | 0.74 (0.59–0.92) | 0.91 (0.84–0.99) | / | / | / | / |
| SSM positive | 0.82 (0.66–1.0) | / | / | / | / | / |
| SSM negative | 0.45 (0.26–0.80) | / | / | / | / | / |
| CRS | ||||||
| Overall | 0.59 (0.50–0.70) | 0.96 (0.93–0.99) | / | / | / | / |
| HIV infected | 0.67 (0.64–0.70) | 0.94 (0.92–0.96) | 12.74 (5.83–27.87) | 0.39 (0.30–0.50) | 34.95 (16.04–76.17) | 0.83 |
| CD4 cell > 200 | 0.36 (0.28–0.45) | 0.99 (0.97–1.0) | 27.52 (10.0–75.68) | 0.65 (0.57–0.74) | 42.91 (14.51–126.95) | / |
| CD4 cell ≤ 200 | 0.75 (0.71–0.78) | 0.90 (0.86–0.93) | 7.71 (2.29–25.96) | 0.29 (0.21–0.41) | 25.64 (6.79–96.75) | / |
| Frozen urine samples | 0.69 (0.65–0.72) | 0.94 (0.91–0.97) | / | / | / | / |
| Fresh urine samples | 0.49 (0.41–0.59) | 0.99 (0.97–1.00) | / | / | / | / |
| Cerebrospinal fluid | 0.52 (0.40–0.68) | 0.98 (0.91–1.00) | / | / | / | / |
LR, likelihood ratio; OR, odds ratio; SROC, summary receiver operator characteristic curve; MRS, microbiological reference standard; CRS, comprehensive reference standard; HIV, human immunodeficiency virus; SSM, sputum smear microscopy.