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. 2021 Oct 20;2(1):453–460. doi: 10.1089/neur.2021.0031

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© John B. Redell et al., 2021; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 3. — Spatial memory in CCI-injured mice was not enhanced by pre-training IGF-2 administration. (A) Experimental timeline. (B) Summary data (n = 7 per group) showing that there was no significant difference in acquisition of the hidden platform location between vehicle- and IGF-2-treated injured mice during training. When tested for their long-term memory, there were no significant differences detected between vehicle- and IGF-2-treated CCI mice in either (C) latency to the first platform crossing, (D) the number of platform crossings, or (E) time spent in concentric circles centered on the platform location. All data are presented as the mean ± SEM. CCI, controlled cortical impact; IGF-2, insulin-like growth factor-2; SEM, standard error of the mean; Veh, vehicle.