Table 1.
Dose Modification
| Dose level | Gemcitabine, mg/m2 | Cobimetinib, mg |
|---|---|---|
| Full dose | 1250 | 20 mg b.i.d. orally |
| Level 1 | 1000 | 20 mg once per day orally |
| Level 2 | 750 | None |
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