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. 2021 Dec 7;8(1):e647. doi: 10.1212/NXG.0000000000000647

Figure 1. Family Pedigree Demonstrating F386L Segregates With Early-Onset AD.

Figure 1

III-24 (arrow) is the proband. III-39 (gray symbol) is cognitively normal but amyloid PET positive. A solid black symbol indicates that the individual was either clinically diagnosed with AD by the authors or the family provided sufficient medical record detail of the diagnosis. A half-black symbol indicates that the individual was suspected by the family to have been affected but was not formally diagnosed. Additional clinical and anecdotal information is included in eAppendix 2, links.lww.com/NXG/A504. Plus (+) and minus (−) signs indicate F386L carrier or noncarrier status (genetic testing described in eAppendix 3, links.lww.com/NXG/A504). Females are depicted as circles and males as squares. Ages represent age at death (for those marked as deceased with a diagonal line through the symbol) or current age.