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. 2021 Nov 25;9:757184. doi: 10.3389/fcell.2021.757184

FIGURE 11.

FIGURE 11

The illumination of the effect of ATG5 expression and methylation in cervical cancer. ATG5 among these 32 ARGs was the most significant harmful factor affecting the prognosis of CESC patients. ATG5 co-expressed genes involved in the regulation of the immune effector process were A2M, C1QA, C1QB, C1QC, RPS19, MAP3K7, TYROBP, STX7, and IL20RB. And, MAP3K7, STX7, and IL20RB were in-volved in the regulation of T cell-mediated immunity. Moreover, ATG5 might promote the migration and invasion of CESC by the regulation of N-cadherin, Vimentin, P-ERK, P-NFκBp65, P-mTOR, MMP-9, and Twist. ATG5 was also significantly correlated with EMT signature related genes including DPH3, CD24, KRT8, CTNNAL1, EPCAM, TSPAN13, MYB, TPD52, ECHDC1, CLSPN, USP33, TTK, TOM1L1, GCA, COMMD8, CGAS, and OSTM1. ATG5 methyltaion status also influence CESC OS. Among these 19 methylation sites in ATG5, four sites significantly increased while other four sites significantly decreased OS of cervical cancer patients.