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. 2021 Nov 22;6(48):32896–32903. doi: 10.1021/acsomega.1c04891

Scheme 2. Test Reactions of Hydrodabcyl Active Ester 3 with Primary and Secondary Amines (in Blue).

Scheme 2

(A) 1.2 equiv. Isopropylamine, DMF; 99%; (B) 1.1 equiv. Glycine Methyl Ester Hydrochloride, 1.1 equiv. NEt3, DMF, r.t., Overnight; 99%; (C) l-threonine Benzylester Oxalate, 2 equiv. NEt3, DMF, r.t., Overnight; 70%; (D) 2 equiv. l-proline, 2 equiv. NEt3, DMF, r.t., Overnight; 92%; and (E) Two-Step Reaction: i. 2 equiv. l-lysine Copper(II) Complex 10, Water/DMF and ii. 25 mL of 0.1% Na2EDTA Solution; 30%. More details are provided in the Supporting Information.