TABLE 1.
The baseline features of the TCGA, METABRIC and GSE3494 cohorts.
| Characteristics | TCGA | METABRIC | GSE3494 |
|---|---|---|---|
| Number | n = 960 | n = 1900 | n = 234 |
| Age(average) | 58 | 61.1 | 62.7 |
| Race(%) | |||
| White | 666 (69.4) | — | |
| Black | 168 (17.5) | — | - |
| Asian and other | 52 (5.4) | — | — |
| NA | 74 (7.7) | — | — |
| Tumor grade(%) | |||
| G1 | — | 164 (8.6) | 62 (2.5) |
| G2 | — | 740 (38.9) | 120 (51.3) |
| G3 | — | 925 (48.7) | 50 (21.4) |
| NA | — | 71 (3.7) | 2 (0.9) |
| Histological type(%) | |||
| IDC | 704 (73.3) | 1450 (76.3) | — |
| ILC | 191 (19.9) | 142 (7.5) | — |
| Other | 65 (6.8) | 308 (16.2) | |
| Menopause status(%) | |||
| Pre | 209 (21.8) | 411 (21.6) | — |
| Post | 616 (64.2) | 1489 (78.4) | — |
| Peri | 37 (3.9) | — | — |
| NA | 98 (10.2) | — | — |
| ER status (%) | |||
| Positive | 716 (74.6) | 1457 (76.7) | 200 (87) |
| Negative | 443 (23.3) | 30 (13) | |
| NA | 41 (4.3) | — | |
| PR status (%) | |||
| Positive | 624 (65) | 1007 (53) | 178 (76.1) |
| Negative | 893 (47) | 56 (23.9) | |
| NA | 43 (4.5) | 0 | — |
| HER2 status (%) | |||
| Positive | 169 (17.6) | 236 (12.4) | — |
| Negative | 672 (70) | 1667 (87.7) | — |
| NA | 122 (12.7) | 0 | — |
| Molecular subtype | |||
| HR+/Her2- | 535 (56) | 1378 (73) | — |
| HR+/Her2+ | 132 (14) | 104 (5) | — |
| HR-/Her2+ | 33 (3) | 132 (7) | — |
| TNBC | 135 (14) | 299 (16) | — |
| NA | 125 (13) | — | — |
| TNM stage(%) | |||
| 0 | — | 4 (0.2) | — |
| I | 166 (17.3) | 473 (24.9) | — |
| II | 545 (56.8) | 800 (42.1) | — |
| III | 211 (22) | 115 (6.1) | — |
| IV | 18 (1.9) | 9 (0.5) | — |
| NA | 20 (2.1) | 499 (26.3) | — |
| follow up state(%) | |||
| alive | 883 (92) | 1279 (67.3) | 180 (76.9) |
| dead | 77 (8) | 621 (32.7) | 54 (23.1) |
| DSS years (median) | 2.5 | 9.5 | 10.2 |
IDC: invasive ductal carcinoma, ILC: invasive lobular carcinoma.