Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 25;9:720472. doi: 10.3389/fcell.2021.720472

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Fu, Shen, Tong, Huang, Cheng and Zhong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Anti-TNFR2 antibody decreases the percentage of regulatory T cells (Tregs) in CD4⁺ T-cell population and downregulates TNFR2 expression. (A) Fluorescence-activated cell sorting (FACS) analysis of Foxp3 intracellular staining in CD4⁺ T cells after anti-TNFR2 antibody treatment. (B) FACS analysis of TNFR2 expression in CD4⁺Foxp3⁺ Tregs after anti-TNFR2 antibody treatment. Dotted line: TNFR2 antibody isotype IgG staining. Solid line: TNFR2 staining. (C) Summarized data of the proportion of CD4⁺Foxp3⁺ Tregs in CD4⁺ T-cell population. (D) Summary of the percentage of TNFR2-positive cells. Data are the summary of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001.