Table 3.

Comparison with other methods for detection of residues and contaminants in meat

Target compounds	Matrix	Sample preparation and clean up	Stationary phase	Tandem MS system	Most important differences in the method	LOQ ranges	References
84 veterinary drugs	Muscle	Liquid extraction with ethylenediamine tetraacetic acid (EDTA-succinate buffer and acetonitrile, followed by phase separation and evaporation of the supernatant	RP-LC column (pentafluoro- phenylpropyl)	MS/MS	Different extraction solvents Sample preparation without SPE extraction Different LC column Pesticides and mycotoxins are not included	2–48 µg/kg	[3]
28 Pesticides, Plant Hormone, Veterinary Drugs and Mycotoxins	Food matrices (including meat)	Liquid–liquid extraction with acidified methanol with formic acid	ZIC-pHILIC	MS/MS	Different extraction solvents Sample preparation without SPE extraction Different LC column Anabolic hormones, β-agonists, lactones, some class of antibiotics and zearalenone are not included Included only 2 pesticides	1–10 µg/kg	[5]
More than 300 veterinary drugs and pesticides	meat, fish and vegetables as baby food samples	Liquid–liquid extraction with acetonitrile containing formic acid followed by SPE extraction (Florisil cartridge)	C18 column	Orbitrap QqQ/MS	Different extraction solvents SPE extraction with different type of cartridge Different MS detector Mycotoxins are not included	10–100 µg/kg	[11]
100 veterinary drugs	Muscle	Liquid extraction with EDTA-succinate buffer and acetonitrile, followed by SPE extraction (Oasis HLB, 200 mg/6 ml)	HSS-T3	TOF	Different extraction solvents SPE extraction with different type of HLB cartridge Different LC column Different MS detector Pesticides and mycotoxins are not included	< 5 µg/kg	[12]
41 veterinary drugs	Muscle	QuEChERS (SPE extraction with Bond Elut SCX cartridge is additional step for extraction of nitroimidazoles)	C18 column	MS/MS	Different extraction solvents SPE extraction with different type of cartridge Pesticides and mycotoxins are not included	n/a*	[17]
128 Veterinary drugs, pesticides	Muscle	QuEChERS	C18 column	MS/MS	Different extraction solvents Sample preparation without SPE extraction Anabolic hormones, β-agonists, lactones, some class of antibiotics and mycotoxins are not included	n/a*	[19]
130 Veterinary drugs	Muscle	liquid–liquid extraction with acetonitrile: methanol followed by delipidation with n-hexane saturated with acetonitrile	C18 column	MS/MS	Different extraction solvents Sample preparation without SPE extraction Pesticides and mycotoxins are not included	0.1–10 µg/kg	[22]
226 veterinary drugs, pesticides, mycotoxins	Muscle	liquid–liquid extraction (EDTA–Na2, acetonitrile–ethanol, n-hexane), purification by low temperature clean-up (− 40 °C/2 h) and dispersive solid-phase extraction (D-SPE)	HSS-T3	MS/MS	Different extraction solvents Sample preparation without SPE extraction Different LC column Different temperature and time for low temperature clean-up (80 °C/20 min)	0.05–10 µg/kg	[24]

*n/a not applicable