Table 2.
Stratified analyses of IL-6 and IL-10 genes’ common polymorphisms on cirrhosis of liver risk
| Variables | N | Case/ | Allelic contrast | Heterozygote comparison | Dominant model |
|---|---|---|---|---|---|
| Control | OR(95%CI) Ph P I-squared | OR(95%CI) Ph P I-squared | OR(95%CI) Ph P I-squared | ||
| IL-10 -592 | |||||
| Total | 19 | 2019/2403 | 1.15 (0.98–1.37)0.000 0.093 65.7% | 1.30 (1.01–1.67)0.006 0.03950.9% | 1.34 (1.04–1.72)0.001 0.02157.5% |
| Ethnicity | |||||
| Asian | 13 | 1506/1867 | 1.25 (1.01–1.55)0.000 0.042 72.3% | 1.40 (1.03–1.88)0.001 0.02963.1% | 1.47 (1.09–1.99)0.000 0.01368.3% |
| Caucasian | 4 | 426/384 | 0.98 (0.78–1.22)0.270 0.840 23.4% | 1.26 (0.74–2.14)0.728 0.399 0.0% | 1.24 (0.76–2.02)0.747 0.395 0.0% |
| SOC | |||||
| HB | 14 | 1483/1790 | 1.19 (0.95–1.48)0.000 0.125 73.6% | 1.36 (0.98–1.89)0.001 0.06863.5% | 1.40 (1.01–1.96)0.000 0.04668.2% |
| PB | 5 | 536/613 | 1.11 (0.93–1.33)0.594 0.234 0.0% | 1.17 (0.88–1.57)0.917 0.277 0.0% | 1.19 (0.91–1.56)0.897 0.208 0.0% |
| Disease type | |||||
| PBC | 5 | 484/498 | 1.11 (0.91–1.35)0.590 0.319 0.0% | 1.23 (0.85–1.78)0.908 0.281 0.0% | 1.27 (0.89–1.79)0.871 0.184 0.0% |
| HBV-LC | 6 | 466/730 | 1.46 (0.86–2.49)0.000 0.163 35.9% | 2.24 (0.95–5.28)0.000 0.06584.0% | 2.26 (0.95–5.38)0.000 0.06586.3% |
| HCV-LC | 4 | 222/311 | 0.98 (0.75–1.28)0.161 0.901 41.8% | 0.93 (0.53–1.64)0.531 0.794 0.0% | 0.98 (0.59–1.62)0.572 0.926 0.0% |
| -819 | |||||
| Total | 12 | 1134/1549 | 1.07 (0.88–1.30)0.017 0.485 52.4% | 1.14 (0.86–1.51)0.072 0.35440.3% | 1.15 (0.86–1.53)0.029 0.35448.8% |
| Ethnicity | |||||
| Asian | 9 | 938/1304 | 1.05 (0.82–1.34)0.006 0.089 63.0% | 1.18 (0.86–1.64)0.047 0.30449.0% | 1.17 (0.83–1.64)0.016 0.36757.2% |
| Caucasian | 2 | 159/143 | 1.28 (0.90–1.83)0.790 0.173 0.0% | 1.23 (0.64–2.34)0.542 0.537 0.0% | 1.33 (0.74–2.39)0.493 0.334 0.0% |
| SOC | |||||
| HB | 7 | 608/922 | 1.14 (0.88–1.47)0.037 0.321 55.2% | 1.22 (0.78–1.91)0.020 0.38660.2% | 1.23 (0.80–1.91)0.016 0.34361.5% |
| PB | 5 | 526/627 | 0.96 (0.68–1.36)0.045 0.832 58.9% | 1.07 (0.81–1.42)0.543 0.614 0.0% | 1.08 (0.83–1.40)0.229 0.556 28.8% |
| Disease type | |||||
| PBC | 4 | 313/357 | 1.24 (0.97–1.57)0.964 0.082 0.0% | 1.37 (0.95–1.99)0.906 0.095 0.0% | 1.38 (0.97–1.96)0.911 0.071 0.0% |
| HBV-LC | 3 | 138/406 | 1.55 (0.55–4.43)0.004 0.409 81.6% | 2.96 (0.70–12.47)0.0320.14070.8% | 2.68 (0.67–10.74)0.0240.16573.2% |
| HCV-LC | 2 | 133/212 | 0.92 (0.66–1.27)0.901 0.595 0.0% | 0.65 (0.38–1.14)0.457 0.132 0.0% | 0.71 (0.42–1.20)0.467 0.203 0.0% |
| -1082 | |||||
| Total | 18 | 1741/2776 | 1.01 (0.85–1.20)0.013 0.892 47.5% | 1.01 (0.82–1.23)0.202 0.941 21.2% | 1.00 (0.80–1.24)0.053 0.971 37.9% |
| Ethnicity | |||||
| Asian | 12 | 1412/2103 | 0.94 (0.76–1.17)0.018 0.577 51.9% | 1.01 (0.78–1.33)0.092 0.921 37.5% | 0.96 (0.72–1.29)0.024 0.795 50.2% |
| Caucasian | 3 | 220/473 | 1.25 (0.94–1.65)0.323 0.122 11.4% | 1.20 (0.78–1.85)0.900 0.409 0.0% | 1.30 (0.86–1.95)0.699 0.213 0.0% |
| African | 2 | 72/98 | 1.27 (0.82–1.97)0.817 0.282 0.0% | 1.12 (0.47–2.70)0.241 0.799 27.2% | 1.24 (0.55–2.82)0.269 0.602 18.0% |
| SOC | |||||
| HB | 10 | 902/1797 | 1.04 (0.89–1.21)0.502 0.601 0.0% | 1.11 (0.90–1.37)0.734 0.319 0.0% | 1.09 (0.90–1.32)0.683 0.380 0.0% |
| PB | 8 | 839/979 | 0.99 (0.72–1.36)0.005 0.966 65.8% | 0.86 (0.56–1.33)0.087 0.505 43.7% | 0.87 (0.53–1.42)0.016 0.577 59.3% |
| Disease type | |||||
| PBC | 5 | 374/687 | 1.30 (1.01–1.68)0.568 0.043 0.0% | 1.32 (0.93–1.89)0.901 0.122 0.0% | 1.39 (0.98–1.95)0.863 0.061 0.0% |
| HBV-LC | 5 | 297/611 | 0.97 (0.71–1.32)0.318 0.827 15.2% | 1.30 (0.89–1.90)0.527 0.170 0.0% | 1.15 (0.80–1.67)0.420 0.447 0.0% |
| HCV-LC | 4 | 205/310 | 0.98 (0.76–1.28)0.547 0.897 0.0% | 0.81 (0.53–1.24)0.865 0.332 0.0% | 0.85 (0.58–1.26)0.489 0.414 0.0% |
| LC | 2 | 559/572 | 0.72 (0.60–0.85)0.987 0.000 0.0% | 0.64 (0.44–0.93)0.865 0.019 0.0% | 0.56 (0.39–0.80)0.892 0.001 0.0% |
| IL-6 -174 | |||||
| Total | 6 | 590/861 | 1.17 (0.73–1.86)0.002 0.511 77.5% | 1.42 (0.70–2.87)0.000 0.330 78.3% | 1.37 (0.71–2.63)0.001 0.346 77.2% |
| Ethnicity | |||||
| Caucasian | 3 | 410/501 | 0.89 (0.73–1.09)0.631 0.244 0.0% | 0.87 (0.65–1.15)0.314 0.316 13.7% | 0.86 (0.66–1.12)0.550 0.257 0.0% |
| SOC | |||||
| HB | 3 | 198/305 | 1.98 (0.55–7.05)0.001 0.294 86.8% | 2.79 (0.41–18.88)0.000 0.294 90.4% | 2.71 (0.47–15.57)0.0000.26589.6% |
| PB | 3 | 392/556 | 0.99 (0.63–1.55)0.083 0.961 59.8% | 1.04 (0.76–1.42)0.130 0.800 50.9% | 0.98 (0.73–1.32)0.110 0.916 54.7% |
| −572 | |||||
| Total | 4 | 1131/864 | 1.15 (0.97–1.36)0.859 0.117 0.0% | 2.23 (0.80–6.21)0.000 0.127 89.2% | 1.60 (0.83–3.06)0.005 0.157 76.3% |
| −597 | |||||
| Total | 2 | 280/374 | 0.84 (0.66–1.08)0.453 0.168 0.0% | 0.88 (0.63–1.23)0.203 0.462 38.3% | 0.84 (0.61–1.15)0.278 0.283 15.0% |
Ph: value of Q-test for heterogeneity test; P: Z-test for the statistical significance of the OR