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. 2021 Nov 25;9:795150. doi: 10.3389/fchem.2021.795150

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Copyright © 2021 Lin, Zhang, Liu, Ye, Chen, Huang, Zeng, Liao, Zhan, Zhou and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quantified log10 CFU/thigh in mice at 24 h post-treatment of various treatments. Changes in mouse thigh muscles (Δlog₁₀ cfu/thigh) after 24 h of monotherapy or combination therapy using different dosing regimens against two colistin-resistant strains of E. coli (DC3737) and K. pneumoniae (FK 1913) (n = 6).