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. 2021 Nov 25;8:798095. doi: 10.3389/fmed.2021.798095

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Copyright © 2021 Goldman, Bron, Tousseyn, Vierasu, Dewispelaere, Heimann, Cogan and Goldman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biopsy specimen. (A,B) H&E stainings showing architectural disturbance due to a medium-sized lymphoid population with a clear cell morphology. (C–F) Immunohistochemical stainings establishing the TFH origin of the abnormal cell population: CD3+, CD4+, CD10+ (not shown), ICOS+ (C), PD1 (D), BCL6 (E) and expression of CD30 (F). CD21 staining (G) shows an extended network of follicular dendritic cells. (H) Intermediate sized EBV+ immunoblasts by EBER in situ hybridization. Scalebar: 100 μm.