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. 2021 Nov 25;12:756671. doi: 10.3389/fphar.2021.756671

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Copyright © 2021 Su, Yu, Wang, Li, Li, Bai, Qi, Zhang, Liu, Zhang, Zhu and Kang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of AAV-Ec-SOD on oxidative stress–related indicators in the PVN. (A) Representative immunoblot and (B) densitometric analysis of PVN expression levels of Ec-SOD, NOX2, and NOX4 in different groups. (C) Column diagrams for Ec-SOD activity, (D) NAD(P)H oxidase activity, (E) MAD level, (F) GSH level in the PVN of different groups. Values are expressed as mean ± SEM (n = 4–6). ^& p < 0.05 AAV-Ctrl vs. AAV-Ec-SOD; *p < 0.05 NS + PVN AAV-Ctrl vs. HS + PVN AAV-Ec-SOD; ^# p < 0.05 HS + PVN AAV-Ctrl vs. HS + PVN AAV-Ec-SOD.