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. 2021 Nov 25;12:700933. doi: 10.3389/fimmu.2021.700933

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Copyright © 2021 Yang, Do-Umehara, Zhang, Wang, Hou, Dong, Perez, Sala, Anekalla, Walter, Liu, Wunderink, Budinger and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Loss of JNK2 aggravates lung inflammation and injury in mouse model of LPS-induced acute lung injury. Wild-type and JNK2 KO mice were subjected to i.t. LPS-induced ALI. Two days later, mice were harvested. (A, B) Protein content (A) and production of MCP-1 (B) in the BAL fluid. PBS: N=3-6. LPS: N=5-6. (C) mRNA expressions of inflammatory cytokines in whole lung homogenates as indicated. N=4. (D) Sectional lung histology from PBS- or LPS-treated wild-type and JNK2 KO mice. Data are presented as means ± sem. *p < 0.05; **p < 0.01; ***p < 0.001.