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. 2021 Nov 25;12:700933. doi: 10.3389/fimmu.2021.700933

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Copyright © 2021 Yang, Do-Umehara, Zhang, Wang, Hou, Dong, Perez, Sala, Anekalla, Walter, Liu, Wunderink, Budinger and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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JNK2 mRNA levels are also negatively correlated with lung injury severity in LPS-induced ALI model. (A) mRNA expressions of JNK2 or inflammatory cytokines in whole lung homogenates of wild-type mice treated with i.t. LPS. (B) Left panel, gating strategy to flow sort AT2 cells and AMs from PBS-treated mouse lung. Middle panel, JNK2 protein expression in AT2 cells and AMs flow-sorted from PBS- or LPS-treated whole lung homogenates. Right panel, JNK2 mRNA level in AT2 cells flow-sorted from PBS- or LPS-treated mouse lung. N=3-6. Data are presented as means ± sem. ***p < 0.001; ****p < 0.0001; ns, not significant.