Table 1. . Coefficient of drug interaction values for drug combinations.
| Parameters | JQ1 + venetoclax | JQ1 + panobinostat | JQ1 + ibrutinib | |||
|---|---|---|---|---|---|---|
| Mean CDI ± SD | Description | Mean CDI ± SD | Description | Mean CDI ± SD | Description | |
| Cell viability | ||||||
| BCWM.1 | 0.721 ± 0.116 | Moderate synergy | 0.498 ± 0.058 | Synergy | 0.846 ± 0.023 | Moderate synergy |
| MWCL-1 | 0.793 ± 0.032 | Moderate synergy | 0.544 ± 0.169 | Synergy | 0.820 ± 0.052 | Moderate synergy |
| RPCI-WM1 | 0.594 ± 0.214 | Synergy | 0.506 ± 0.084 | Synergy | 0.887 ± 0.086 | Slight synergy |
| JQ1 + venetoclax | ||||||
|---|---|---|---|---|---|---|
| Mean CDI ± SD | Description | |||||
| Cell proliferation | ||||||
| BCWM.1 | 0.834 ± 0.130 | Moderate synergy | ||||
| MWCL-1 | 1.081 ±.262 | Additive | ||||
| RPCI-WM1 | 0.762 ± 0.305 | Moderate synergy | ||||
CDI: Coefficient of drug interaction; SD: Standard deviation.