Fig. 4.

Therapeutic administration of DON reduced innate inflammatory response in the TGs. C57BL/6 mice were infected ocularly with HSV-1, DON (0.3 mg/kg) and PBS was administered from day 6 till 15 PI and FACS analysis was performed on day 15 PI. Histograms and plot analysis represent frequencies (A and B) and total number (C) of leukocytes, the frequencies (D and E) and total numbers (F) of neutrophils (CD45⁺CD11b⁺Ly6G⁺) and the frequencies (G and H) and numbers (I) of macrophages (CD45⁺CD11b⁺F4/80⁺). The data represent mean results ± SEM. All data were analysed by Mann-Whitney U test (experiments repeated three times with n=6).