Table 3.
Functional brain networks associated with melancholic depression symptoms.
| Network | Anatomical locations of functional ROIs | Depressive symptoms | |
|---|---|---|---|
| Basal ganglia network (BGN) |
(1) | Left thalamus, caudate | Anhedonia (31) |
| (2) | Right thalamus, putamen | ||
| (3) | Left inferior frontal gyrus | ||
| (4) | Right inferior frontal gyrus | ||
| (5) | Pons | ||
| Dorsal default mode network (DDMN) |
(1) | Medial prefrontal cortex, anterior cingulate cortex, orbitofrontal cortex | Anhedonia (33) Rumination (34) |
| (2) | Left angular gyrus | ||
| (3) | Right superior frontal gyrus | ||
| (4) | Posterior cingulate cortex, precuneus | ||
| (5) | Midcingulate cortex | ||
| (6) | Right angular gyrus | ||
| (7) | Left and right thalamus | ||
| (8) | Left hippocampus | ||
| (9) | Right hippocampus | ||
| Left executive control network (LECN) |
(1) | Left middle frontal gyrus, superior frontal gyrus | Rumination (32) Impaired cognitive reappraisal (14, 35) |
| (2) | Left inferior frontal gyrus, orbitofrontal gyrus | ||
| (3) | Left superior parietal gyrus, inferior parietal gyrus, precuneus, angular gyrus | ||
| (4) | Left inferior temporal gyrus, middle temporal gyrus | ||
| (5) | Left thalamus |
Three primary functional networks referenced throughout this main paper. For full list of networks, see Supplementary Table 1.