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. 2021 Nov 25;12:738812. doi: 10.3389/fmicb.2021.738812

TABLE 2.

Pharmacokinetic parameters (means ± SDs) used in the Monte Carlo simulations.

Antibiotic ClT (L/h) Fu (%) Vd (L) References
Tigecycline 19.2 ± 7.76 Rubino et al., 2010
Polymyxin B 2.5 ± 0.4 Thamlikitkul et al., 2016
Ceftazidime/avibactam 7.53 ± 1.28 90 18.8 ± 6.54 Bensman et al., 2017

ClT, total body clearance; fu, fraction unbound; SDs, standard deviations; Vd, volume of distribution.