TABLE 2.
Pharmacokinetic parameters (means ± SDs) used in the Monte Carlo simulations.
| Antibiotic | ClT (L/h) | Fu (%) | Vd (L) | References |
| Tigecycline | 19.2 ± 7.76 | — | — | Rubino et al., 2010 |
| Polymyxin B | 2.5 ± 0.4 | — | — | Thamlikitkul et al., 2016 |
| Ceftazidime/avibactam | 7.53 ± 1.28 | 90 | 18.8 ± 6.54 | Bensman et al., 2017 |
ClT, total body clearance; fu, fraction unbound; SDs, standard deviations; Vd, volume of distribution.