TABLE 6.

CFR values for three antibiotics against CRE.

Antimicrobials	CRE	Dosing regimens	CFR (%)
Tigecycline	CRKP	50 mg every 12 h	69.22
		75 mg every 12 h	83.12
		100 mg every 12 h	91.15
	CREC	50 mg every 12 h	91.45
		75 mg every 12 h	95.53
		100 mg every 12 h	96.77
	CRE species except CRKP and CREC	50 mg every 12 h	85.14
		75 mg every 12 h	92.53
		100 mg every 12 h	95.62
Polymyxin B	CRKP	1.25 mg/kg every 12 h	82.84
		1.5 mg/kg every 12 h	86
		2.5 mg/kg per day continuous infusion	82.79
	CREC	1.25 mg/kg every 12 h	82.6
		1.5 mg/kg every 12 h	86.05
		2.5 mg/kg per day continuous infusion	82.3
	CRE species except CRKP and CREC	1.25 mg/kg every 12 h	77.05
		1.5 mg/kg every 12 h	79.99
		2.5 mg/kg per day continuous infusion	76.31
Ceftazidime/avibactam	CRKP	1.25 g every 8 h	82.48
		2.5 g every 8 h	91.78
	CREC	1.25 g every 8 h	67.79
		2.5 g every 8 h	86.33
	CRE species except CRKP and CREC	1.25 g every 8 h	19.63
		2.5 g every 8 h	29.12

CFR, cumulative fraction of response; CRE, carbapenem-resistant Enterobacterales; CRKP, carbapenem-resistant Klebsiella pneumoniae; CREC, carbapenem-resistant Escherichia coli.