Table 3.

Factors associated with T-cell-secreting cytokines in multivariate linear regression analysis.

Variables		IFN-γ+/CD8+T			TNF-α+/CD8+T
		B (95% CI)	β	p	B (95% CI)	β	p
Age (years)		1.99 (0.68, 3.31)	0.73	0.004	0.54 (−0.08, 1.16)	0.42	0.088
Gender (male vs. female)		2.62 (−2.40, 7.63)	0.13	0.301	0.14 (−2.22, 2.51)	0.02	0.904
ALT/ULN		2.62 (−2.40, 7.63)	0.24	0.071	0.28 (0.01, 0.55)	0.27	0.045
HBV DNA (log10 IU/ml)		0.53 (−0.05, 1.10)	0.35	0.099	0.31 (−0.75, 1.37)	0.12	0.561
HBeAg (+ vs. –)		1.88 (−0.36, 4.12)	−0.26	0.202	−1.01 (−7.38, 5.36)	−0.06	0.752
Genotype (genotype C is the reference group)	B	−8.70 (−22.2, 4.81)	−0.30	0.058	−1.42 (−4.53, 1.70)	−0.14	0.367
	N	−6.40 (−13.01, 0.21)	0.11	0.537	1.47 (−1.79, 4.73)	0.16	0.370
CD8+T/lymphocyte (%)		2.14 (−4.77, 9.05)	−0.02	0.886	−0.03 (−0.21, 0.14)	−0.05	0.717
Tcm/CD8+T (%)		0.30 (−0.18, 0.77)	0.20	0.218	0.06 (−0.16, 0.29)	0.09	0.585
Tem/CD8+T (%)		−0.17 (−0.86, 0.51)	−0.07	0.612	0.27 (−0.05, 0.59)	0.22	0.099
Teff/CD8+T (%)		0.18 (−0.08, 0.43)	0.24	0.164	0.14 (0.02, 0.26)	0.40	0.026
CD38+/CD8+T (%)		0.41 (0.05, 0.77)	0.55	0.025	0.05 (−0.12, 0.22)	0.15	0.539
CD4+T/lymphocyte (%)		−0.37 (−0.85, 0.11)	−0.25	0.128	−0.02 (−0.24, 0.21)	−0.03	0.878
Tcm/CD4+T (%)		−0.33 (−1.01, 0.36)	−0.28	0.343	−0.21 (−0.54, 0.11)	−0.38	0.190
Tem/CD4+T (%)		−1.56 (−2.75, −0.37)	−0.66	0.011	−0.31 (−0.87, 0.26)	−0.28	0.280
Teff/CD4+T (%)		0.44 (−2.35, 3.23)	0.04	0.753	0.00 (−1.31, 1.32)	0.00	0.997
CD38+/CD4+T (%)		−0.25 (−1.02, 0.52)	−0.28	0.515	−0.11 (−0.48, 0.25)	−0.27	0.536

CD8+Tnaive and CD4+Tnaive cells were excluded from the regression model due to multicolinearity.

N, not detected; CI, confidence interval; ALT, alanine aminotransferase; HBeAg, HBV e antigen. The bold values mean p < 0.05.