Table 1.
Demographic characteristics across the spectrum of ALS-FTD.
| ALSpure (n = 64) | ALSci(n = 23) | ALSbi (n = 16) | ALScbi(n = 12) | bvFTD (n = 98) | ALS-FTD(n = 37) | F | p | Post-hoc | |
|---|---|---|---|---|---|---|---|---|---|
| Sex (M/F) | 33/31 | 13/10 | 10/6 | 5/7 | 61/37 | 27/10 | 6.499a | 0.261 | - |
| Age (Y) | 61.54 (9.91) | 59.83 (9.71) | 60.81 (9.53) | 66.75 (11.55) | 62.98 (8.66) | 63.84 (7.96) | 1.356 | 0.241 | - |
| Education (Y) | 13.52 (3.30) | 12.35 (2.90) | 14.13 (3.81) | 10.42 (3.12) | 12.22 (2.94) | 12.28 (3.40) | 3.333 | 0.006 | ALSpure,ALSbi > ALScbi |
| Disease duration (M) | 26.44 (30.98) | 46.65 (80.01) | 32.25 (22.12) | 23.67 (18.58) | 53.48 (36.17) | 33.89 (22.72) | 6.723b | <0.001 | bvFTD > ALSpure, ALSbi, ALScbi, ALS-FTD |
| Onset Site (Bulbar/Limb) | 25/39 | 10/13 | 5/11 | 7/5 | - | - | 2.278a | 0.517 | - |
| C9orf72 status (Y/N) | 9/44 | 3/18 | 1/12 | 1/9 | 13/77 | 7/24 | 2.199a | 0.821 | - |
| King's staging (1/2/3/4) | 32/14/14/4 | 9/6/8/0 | 4/3/7/2 | 2/4/4/2 | - | - | 11.481a | 0.244 | - |
| ACE Total (/100) | 92.19 (5.81) | 86.52 (8.21) | 91.73 (7.70) | 75.17 (8.97) | 66.07 (20.73) | 60.70 (18.10) | 48.624b | <0.001 | All ALS groups > ALS-FTD & bvFTD |
| ALSpure > ALScbi |
Means (Standard Deviation).
a
Chi-square value.
b
Welch's F value.
ACE, Addenbrooke's Cognitive Examination; ALSbi, amyotrophic lateral sclerosis with behavioral impairment; ALSci, amyotrophic lateral sclerosis with cognitive impairment; ALScbi, amyotrophic lateral sclerosis with combined cognitive and behavioral impairment; ALSpure, amyotrophic lateral sclerosis with no cognitive or behavioral impairment; ALS-FTD, amyotrophic lateral sclerosis-frontotemporal dementia-motor neuron disease; bvFTD, behavioral-variant frontotemporal dementia.