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. 2021 Nov 25;12:767590. doi: 10.3389/fgene.2021.767590

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Copyright © 2021 Zhang, Zhao, Yuan, Wu, Liu, Sun, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CircARVCF was overexpressed in DDP-resistant GC tissues and cells. (A) CircARVCF expression in GC tissues and normal tissues was detected via qRT-PCR. (B) CircARVCF expression in GES-1, N87, HGC-27, MKN-45, and AGS cells was detected by qRT-PCR. (C) CircARVCF expression in DDP-resistant GC tissues and DDP-sensitive GC tissues was detected by qRT-PCR. (D) CircARVCF expression in MKN-45, MKN-45/DDP, AGS, and AGS/DDP cells was detected by qRT-PCR. (E,F) IC50 of cisplatin in MKN-45, MKN-45/DDP, AGS, and AGS/DDP cells was assessed by CCK-8 assay. (G,H) The levels of circARVCF and ARVCF in MKN-45/DDP and AGS/DDP cells treated with Actinomycin D were examined by qRT-PCR. (I,J) Total RNA in MKN-45/DDP and AGS/DDP cells was treated with RNase R and then circARVCF and linear ARVCF levels were detected by qRT-PCR. *p < 0.05.