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. 2021 Nov 25;12:767590. doi: 10.3389/fgene.2021.767590

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Copyright © 2021 Zhang, Zhao, Yuan, Wu, Liu, Sun, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of miR-1205 reversed the effects of circARVCF knockdown on DDP resistance, cell colony formation, migration, invasion, and apoptosis in DDP-resistant GC cells. MKN-45/DDP and AGS/DDP cells were transfected with si-NC, si-circARVCF#1, si-circARVCF#1+in-miR-NC, or si-circARVCF#1+in-miR-1205. (A,B) IC50 of cisplatin was estimated by CCK-8 assay. (C) The colony formation of MKN-45/DDP and AGS/DDP cells was examined with colony formation assay. (D,E) The migration and invasion of MKN-45/DDP and AGS/DDP cells were assessed by transwell assay. (F) The apoptosis of MKN-45/DDP and AGS/DDP cells was analyzed by flow cytometry analysis. (G,H) The protein levels of MRP1, MDR1, Bcl-2 and Bax in MKN-45/DDP and AGS/DDP cells were measured via western blot assay. *p < 0.05.