Table 2.
Effect of edelfosine on the formation of pancreatic CSC spheroid colonies.
| Treatment | Perimeter (AU) | p | Spheroid Colony Numbers | p |
|---|---|---|---|---|
| Control | 5.46 ± 2.58 | 145 ± 18 | ||
| 1 μM EDLF | 4.01 ± 2.20 | 0.25 | 127 ± 6 | 0.1013 |
| 5 μM EDLF | 1.95 ± 0.73 | 0.0005 | 70 ± 12 | 0.0004 |
| 10 μM EDLF | 1.46 ± 0.70 | 0.0001 | 46 ± 13 | 0.0001 |
| 20 μM EDLF | 1.44 ± 0.60 | 0.0002 | 32 ± 7 | <0.0001 |
Data are from the experiments similar to those depicted in Figure 3. Statistical significance is relative to untreated controls. Perimeter is measured in arbitrary units. The number of tumor spheres in each plate was counted under a stereo microscope. The results are shown as the means ± SD of at least three independent experiments. EDLF, edelfosine; AU, arbitrary units.