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. 2021 Nov 24;13(23):5899. doi: 10.3390/cancers13235899

Figure 3.

Figure 3

Effect of adjuvant chemotherapy (n = 66) on immune related proteins: adjuvant chemotherapy shows non-significant increase in immunostimulation and a mixed effect on immunosuppression (similar results are seen when leaving out stage I ovarian cancer patients, see Figure S5). Proteins in green are immune stimulatory factors, proteins in red are immune inhibitory factors, and proteins in orange have a dual function. *: 0.01 ≤ p-value < 0.05; **: p-value < 0.01. Abbreviations: CCL, C-C motif chemokine ligand; CXCL, C-X-C motif chemokine ligand; IL-10, interleukin-10; MMP, matrix metallopeptidase; ACT, adjuvant chemotherapy; SAA, serum amyloid A; vascular endothelial growth factor (VEGF).