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. 2021 Nov 29;13(23):5998. doi: 10.3390/cancers13235998

Figure 1.

Figure 1

Stromal cells in the colon tumour microenvironment are altered and increase expression of matrix remodelling, ECM and immunomodulation transcripts. (A) Schematic description of how samples from GSE35602 were processed. (B) Volcano plot of tumour-associated stroma (n = 13) versus normal stroma (n = 4) differential mRNA expression (GSE35602). (C) Fold change of mRNA levels related to matrix remodelling (MMP2, MMP3, MMP11) (i), ECM deposition (FN1, VCAN, COL1a1, COL11A1) (ii) and immune modulation (Serpin E1, TGFβ1, CXCL1, CXCL12) (iii) in tumour-associated stroma versus normal stroma (GSE35602). (D) Schematic description of treatment timeline for mMSC TCS conditioning. (E) Gene set enrichment analysis results for control mMSC (blue) (n = 3) and TCM mMSC (Pink) (n = 3) RNAseq. (F) Fold change of mRNA levels related to matrix remodelling (MMP2, MMP3, MMP9, MMP11, MMP13) (i), ECM deposition (FN1, VCAN, COL1a1) (ii) and immune modulation (Serpin E1, TGFβ1, CXCL1, CXCL12) (iii) in normal mMSC versus TCS mMSC. Error bars represent mean ± SD. *** p < 0.001, **** p < 0.0001 by t test.