Table 5.
LncRNAs and meningioma (ANTs: adjacent non-tumor samples).
| lncRNA | Accession Number/Location | Pattern of Expression | Clinical Samples/Animal Model | Assessed Cell Lines | Targets/Regulators | Signaling Pathways | Description | Reference |
|---|---|---|---|---|---|---|---|---|
| SNHG1 | ENSG00000255717/11q12.3 | ↑ | - | CH157-MN, HBL-52, BEN-MEN-1, IOMM-Lee |
miR-556-5p↓, TCF12↑/TCF12 | Wnt/β-catenin | SNHG1 overexpression, indicated by qRT-PCR, has a marked impact on elevating cell proliferation and growth rates and inhibiting apoptosis. | [36] |
| LINC00702 | ENSG00000233117/10p15.1 | ↑ | 88 malignant meningioma and ANTs | OMM-Lee, KT21, CH157-MN, HBL-52, Ben-Men-1 | miR-4652-3p↓, ZEB1↑ | Wnt/β-catenin | This lncRNA overexpression, as formerly showed by qRT-PCR, has a significant correlation with a lower OS rate. Cell migration and proliferation are positively associated with its expression. | [65] |
| LINC00460 | ENSG00000233532/13q33.2 | ↑ | 33 meningioma and 10 normal meninges tissues | IOMM-Lee, CH157-MN, Ben-Men-1 | miR-539↓, MMP-2↑, MMP-9↑, ZEB1↑ | - | LINC00460 escalates cell invasion and proliferation and lowers the apoptosis rate. qRT-PCR was used to evaluate this lncRNA’s expression. | [35] |
| MEG3 | ENSG00000214548/14q32.2 | ↓ | 5 healthy meninges and 32 meningioma tissues | (IOMM-Lee, CH157-MN | miR-29c↑, AKAP12↓ | - | qRT-PCR showed MEG3 downregulation in tumor tissues. Cell cycle progression, proliferation, migration, and invasion are negatively correlated with MEG3 expression. | [66] |