Skip to main content
. 2021 Nov 24;13(23):5900. doi: 10.3390/cancers13235900

Figure 1.

Figure 1

CYCLON protein network exerts oncogenic effects through nucleolar gene expression regulation and cell-cycle dependent functions. (A) CYCLON protein-protein interaction network and associated functions in B593 DLBCL cell line. (B) Gene ontology (GO) enrichment analysis of CYCLON interacting proteins for biological pathway (upper panel) and cellular component (lower panel) classifiers. (C) CYCLON and NPM1 sub-cellular interphase localization in B593 GFP-CYCLON cell line. Images were captured with a confocal microscope. Bar, 2 µm. (D) CYCLON and NPM1 gene expression levels in DLBCL TCGA samples (T) vs. normal B cells (N, from TCGA and GTEx databases), * p < 0.0001. (E) CYCLON and NPM1 gene expression correlation plot in DLBCL TCGA samples, R: Pearson coefficient. TCGA and GTEx data were retrieved through GEPIA interface.