Table 2.

Multivariate bootstrap Cox regression analysis of the significance of independent prognostic variables NPM1, CYCLON and R-IPI. HR: hazard ratio; R-IPI: revised International Prognostic Index, 95% CI: confidence intervals based on bootstrap resampling (1000 replicates, SE: standard error on HR computed using the default method; 3 cases were uninterpretable for NPM1 staining. Schoenfeld residual test: PFS model: global p = 0.74; SOS model: global p = 0.64; Harrell’s C statistic: PFS model: C = 0.74; SOS model: C = 0.76. NPM1 pan-cellular ⁽⁺⁾: n = 14, pan-cellular⁽⁻⁾: n = 83, CYCLON extra-nucleolar⁽⁺⁾: n = 18, extra-nucleolar⁽⁻⁾: n = 79, R-IPI^(high): n = 48, R-IPI^(low): n = 49.

Variable	Category	HR	95% CI	p-Value	SE	HR	95% CI	p-Value	SE
NPM1	pan-cellular(+) versus pan-cellular(−)	5.2	2.1–12.6	<0.001	2.24	5.8	2.5–13.3	<0.001	1.07
CYCLON	extra-nucleolar(+) versus extra-nucleolar(−)	2.9	1.4–6.2	0.002	1.03	2.8	1.2–6.8	0.007	2.67
R-IPI	R-IPI(high) versus R-IPI (low)	3.7	1.5–8.9	0.001	1.46	5.2	2.0–13.6	<0.001	2.38